Effect Of Moringa Leaf Extract (Moringa Oleifera L.) On Incredible Wound Healing In Wistar Strain Male Rats

Abstract

Wounds are one of the main causes that can hinder human activities in daily activities. People generally use traditional plants as medicine. Plants that affect wound healing are plants moringa (Moringa oleifera L.). The content of flavonoids, saponins, and tannins in Moringa leaves is thought to have antibacterial, astringent, and antimicrobial effects. This study aims to determine the effect of moringa leaf extract (Moringa oleifera L.) on wound healing in male Wistar rats. This study was an experimental study using RAL (completely randomized design) using 25 rats who were divided into five groups. Mice were anesthetized with 0.1 mL ketamine and then slashed using a bistro knife. In the negative control group, the rats were not given any treatment, the positive control was given 10% povidone-iodine (Betadine®), and in the treatment groups P1, P2, and P3 were given Moringa leaf extract (Moringa oleiferaL.) with each concentration of 10%, 20% & 40%. Povidone iodine (Betadine®) and various extract concentrations were applied to much as 0.5 ml. The treatment was carried out for 10 days by measuring the length of the wound on D2, D5, and H10. The research results were analyzed using the Shapiro-Wilk normality test and homogeneity test, the results obtained were p> 0.05, which means that they were normally distributed and homogeneous. Followed by the One Way ANOVA analysis test and the results obtained were p <0.05. Then the HSD Post Hoc test was carried out, based on this test it showed that the positive control did not differ significantly from P3, which means that the 40% concentration group had the same ability to heal wounds. Therefore, the optimal concentration of Moringa leaf extract is P3 (40% extract concentration). The optimal dose is at a concentration of 40% of Moringa leaf extract (Moringa oleiferaL.)capable of healing cuts in male white rats of the Wistar strain.