Potential Incompatibility, Instability And Interactions Of Prescriptive Drug Containing Corticosteroids at. dr. Loekmono Hadi Kudus Hospital

Abstract

Drug incompatibility can cause physical reactions, resulting in visible changes, alterations in color, consistency, or gas production. Chemical reactions are caused by molecular changes in one or more components of the solution. Corticosteroids are one of the most frequently prescribed drugs, but they carry the risk of serious side effects if not used rationally. The compounding process often results in incompatibility, instability, and drug interactions. This can reduce the effectiveness of therapy, and medication errors can occur. Compound prescriptions containing corticosteroids need to be evaluated to ensure the safety and stability of the preparation. Drug incompatibility, instability, and drug interactions can cause decreased drug activity or inactivity, the formation of new active ingredients that are toxic or non-toxic, increased toxicity, and organoleptic changes. This study is a type of quantitative data collection prospectively, which focuses on forward-looking observation starting by identifying variables from patient prescription sheets in April-May 2025 at Dr. Loekmono Hadi Kudus Hospital. The total sample in this study was 107 prescription sheets that met the inclusion criteria. The results of the study showed that the classification of patients based on the diagnosis of the most common disease was ISPA 45 (42.1%), the age criteria for recipients of pulveres prescriptions in the 0-5 year age group was the group with the largest number of patients, namely 83 people (77.6%). There was no potential for incompatibility, 0%. There was a potential for instability on the prescription sheet of 99 (92.5%). There was a potential for corticosteroid drug interactions of 2 (1.9%), indicating the presence of drug interactions. The severity of corticosteroid drug interactions that occurred was a moderate interaction of 1 (0.9%) and a major interaction of 1 (0.9%). The conclusion is that on the prescription sheet there was no potential for incompatibility 0%, there was a potential for instability of 99 (92.5%), and there were moderate, minor interactions, there were potential for corticosteroid drug interactions of 2 (1.9%), and the severity of corticosteroid drug interactions was moderate interaction of 1 (0.9%) and major interaction of 1 (0.9%).