The Effect Of Papaya Leaf Infusa (Carica Papaya L.) On Analgesic Effects In Male Swiss Mice
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Abstract
Pain is an unpleasant sensory and emotional experience resulting from tissue damage, either actual or potential or described as damage. One of the traditional plants that can be used as an anti-pain agent is papaya leaves (Carica papaya L.). The compounds in papaya leaves are flavonoids, alkaloids, saponins, and tannins. The mechanism of this compound as an anti-analgesic is by inhibiting the action of the cyclooxygenase enzyme. This will reduce the production of prostaglandins by arachidonic acid thereby reducing pain. This research is experimental with a Post-test-only Control Group Design. The test subjects used 25 male Swiss strain mice and were divided into 4 treatment groups, namely negative control, positive control, and papaya leaf infusion with concentrations of 25% and 75%. Before treatment, mice were fasted and induced with a hot plate. Observations were made by observing the activity and number of jumps and licks of mice for 15 minutes in 1 hour. Numerical data was then processed using SPSS with the One Way ANOVA test. The results showed that papaya leaf infusion was given with concentrations of 25% and 75%. Which has an analgesic effect on mice with an effective concentration of 25%.
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