Antipyretic Activity Of Ethanol Extract Ipomoea Batatas L. On Swiss Webster Mice Induced 5% Peptone

Abstract

Antipyretics are drugs that can reduce high body temperature. This study aims to prove the antipyretic effect of the ethanol extract of Ipomoea batatas L. in Swiss Webster strain male mice induced by 5% peptone. The research design was Post-test Only Control Group Design. This study used a sample of 25 male Swiss Webster mice which were divided into 5 groups. Each consists of 5 tails. Negative control (K1) was given CMC Na 0.5%. The positive control (K2) was given 1.3 mg paracetamol. (K3) Ipomoea batatas L group. dose of 100 mg/kg BW. (K4) Ipomoea batatas L. group 200 mg/kg BW. (K5) Ipomoea batatas L. group 300 mg/kg BW. Mice that had been adapted for 1 week were fasted for 8 hours and then the initial rectal temperature of the mice was measured (T0). Mice were induced subcutaneously with 5% peptone and then the rectal temperature was measured using a digital thermometer (T1). Rectal temperature measurements were performed at 30, 60, 90, 120, 150, and 180 minutes. (Tn). The results of the percentage decrease in temperature in the group (K5) Ipomoea batatas L. at a dose of 300 mg/kg BW were not statistically significantly different from the positive control (Paracetamol), with a p-value of 0.667. In conclusion, the ethanol extract of Ipomoea batatas L. positively contains chemical compounds of flavonoids, alkaloids, and terpenoids which have antipyretic activity