Antipyretic Effect of Combination of Moringa Leaf Extract and Andrographis paniculata Ness on Mice Induced by 5% Peptone

Abstract

Fever is a physiological response of the body to infection or inflammation, characterized by an increase in body temperature above 37.5°C. Antipyretic drugs such as paracetamol are commonly used to reduce fever through the mechanism of prostaglandin inhibition in the central nervous system. The purpose of this study was to determine the antipyretic effectiveness of Moringa oleifera leaf extract and Andrographis paniculata leaf extract in mice induced with 5% peptone, and to compare it with the positive control (paracetamol). The study was conducted in vivo with a pre and post test group design using 30 mice divided into five groups, each consisting of 6 mice. The negative control group (K−) was given 0.5% CMC Na, the positive control (K+) was given 1.3 mg paracetamol, the K1 group was given 400 mg/kg BW of Andrographis paniculata extract, the K2 group was given 400 mg/kg BW of moringa extract, and the K3 group was given a combination of Andrographis paniculata and moringa extracts of 200 mg/kg BW each. Fever induction was carried out by administering 5% peptone, and temperature measurements were taken at 30, 60, 90, 120, 150, and 180 minutes. The results of the analysis showed that the combination of extracts in the K3 group was able to significantly reduce the body temperature of mice, and had comparable effectiveness to the positive control group (paracetamol), with a p value = 0.561 (p> 0.05). Thus, the combination of Andrographis paniculata and moringa leaf extracts has the potential as an alternative natural antipyretic.