ANALGETIC EFFECTIVENESS TEST OF 96% ETHANOL EXTRACT OF KECOMBRANG (ETLINGERA ELATIOR (JACK) R.M. SMITH) LEAVES ON SWISS WEBSTER MENCITES

Abstract

Pain is an unpleasant experience accompanied by tissue damage that can be overcome by administering analgesic drugs. The use of analgesic drugs can have side effects if used excessively, thus treatment with traditional plants becomes an alternative to analgesic therapy. Torch ginger leaf has potential as an analgesic because it has flavonoid compounds, alkaloids, tannins, and saponins as well as active compounds of chlorogenic acid. The purpose of this study was to prove the analgesic effectiveness of 96% ethanol extract of torch ginger leaves on male mice of the Swiss Webster strain. This study used 25 male mice which were grouped into 5 groups. K(-) was given 1% CMC Na, K(+) was given mefenamic acid 1.3 mg, and P(1), P(2), and P(3) were given 96% ethanol extract of torch ginger leaves with a dose of 6 mg, 12 mg, and 24 mg/20 gBW mice. Each test animal was given 1 mL/gBW of mice orally, after 30 minutes the mice were induced by 1% acetic acid as much as 1 mL/gBW of mice, then the number of mice wriggled for 30 minutes with 5-minute intervals. In the results of the normality test and homogeneity test, the value (p>0.05) means that the data is normally distributed and homogeneous, then continued with the One Way Anova test, the value is (p<0.05), then the Tukey test is carried out with the result that there is no significant difference. between the K(+) group and the treatment group at a dose of 24 mg/20 gBW mice, so it can be concluded that the most optimal 96% ethanol extract of torch ginger leaves provides analgesic effectiveness in male Swiss webster strain mice induced by 1% acetic acid is at a dose of 24 mg. /20 gBB mice.