The Effect Of Solid Lipid Concentration On The Physical Stability Of Nanostructured Lipid Carriers (NLC) Coenzyme Q10 Particles

Abstract

Coenzyme Q10 is a natural antioxidant that is unstable and quickly degraded when exposed to light, so it is necessary to choose a delivery system that can improve the stability of coenzyme Q10, extend the adequate time, and deliver coenzyme Q10 to penetrate the stratum corneum and achieve defense. Coenzyme Q10 can be formulated in Nanostructured Lipid Carrier (NLC) preparations by combining solid lipids (Myristic acid), liquid lipids (Caprylic), which are stabilized by surfactants (Span 80 and Tween 80), and co-surfactants (Propylenglykol). This study aims to determine the effect of variations in the concentration of solid lipids (Myristic Acid) on the zeta potential of Coenzyme Q10 Nanostructured Lipid Carrier (NLC) preparations. The concentration of myristic acid used was F1, F2, and F3. Physical characteristics are evaluated 24 hours after the practice is complete. Observations include organoleptic, spreadability, pH, zeta potential, and droplet size. The research data were processed statistically using ANOVA One Way. The results showed that the myristic acid concentration affected zeta potential with a significantly different impact of 0,001 (p-value signifikan < 0,05). Still, the myristic acid concentration did not affect the particle size, with the result not considerably different at 0,966 (p-value signifikan > 0,05).