Formulation and Antipyretic Activity Test Of Transdermal Patch Preparation Containing 96% Ethanol Extract Of Shallot (Allium cepa var. ascalonicum) As a Fever-Reducing Agent
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Abstract
Abstract. Fever is characterized by an increase in body temperature, namely 36.5°C‒37.5°C. Antipyretic drugs consumed
orally can undergo first-pass metabolism (first-pass metabolism). To avoid the occurrence of first-pass metabolism can be given
a transdermal patch. Previous research suggested that shallots contain flavonoids, these compounds have antipyretic or fever-
reducing potential. Shallot extract is formulated in the form of transdermal patches with different concentrations of K-base, F1
5%, F2 10% and F3 15%. Transdermal patch preparation of 96% ethanol extract of shallot (red onion) was evaluated for its
physical properties and antipyretic effect test. The results showed that the concentration variations of shallot extract transdermal
patch preparations did not affect the results of the patch preparation, namely the pH test, weight uniformity test and patch
thickness test, while the tests that affected the results of the patch preparation were the moisture absorption test and the
antipyretic effect test. The results of the antipyretic effect test showed that K+ was comparable to F3 showing the best results
compared to the other groups.
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