Level Of Compliance With The Use Of Anti-Epileptic Medication In Outpatient Patients At RS X Jepara
Main Article Content
Abstract
Epilepsy is a recurrent paroxysmal seizure attack without provocation, with an interval of more than 24 hours. The most common symptom of epilepsy is seizures. Compliance with taking medication in epilepsy patients is one of the important factors for the success of therapy. The purpose of this study was to determine the level of compliance with the use of anti-epileptic drugs at X Hospital Jepara. This study is a descriptive observational study with quantitative data types. Data collection was carried out prospectively in April-May 2023 by observing some objects. The subjects in this study were 70 respondents, and data collection used the MMAS-8 questionnaire. The results of the questionnaire score have 3 categories: high compliance score 8, moderate compliance 6-7, and low compliance <6. Based on this study, it shows that people with epilepsy based on male gender were 39 respondents (55.7%) more than women. Based on age characteristics, the largest number was found in the adult group (26-45 years) at 32 respondents (45.7%). Based on the highest level of education, 32 respondents (45.7%) were at the high school level, while based on occupation, the most were housewives, 23 respondents (32.9%). Based on the profile of drug use, there are 2 therapies, namely a combination of 2 drugs (polytherapy) and monotherapy. The most common use of polytherapy is Valproic acid and Phenytoin, 43 respondents (61.43%), while the most frequently used monotherapy is Phenytoin, 17 respondents (24.29%). Based on the level of compliance, it is relatively low, namely 45 respondents (64.3%). Judging from the characteristics based on age, most are adults (26-45 years), based on gender, the most are male, the highest level of education is high school, and based on occupation, the most are housewives. Based on the profile of the use of polytherapy drugs, the most frequently used are Valproic acid and Phenytoin, while the most frequent monotherapy drug is phenytoin. The level of compliance with the use of outpatient epilepsy medication at X Hospital Jepara is relatively low.
Downloads
Article Details
References
Fardani, R. A., Ustiawaty, J., Utami, E. F., Sukmana, D. J., & Istiqomah, R. R. (2020). Qualitative & quantitative research methods.
Anindya, T., Ngurah, I. G., Budiarsa, K., Putu, D., Purwa, G., (2021). Characteristics of outpatient epilepsy patients at the neurology polyclinic of Sanglah General Hospital in August – December 2018, Journal Medika Udayana, 10(6), pp. 2–6.
Culig, J. and Leppée, M. (2014). 'From morisky to hill-bone; self-report scales for measuring medication adherence.', Collegium anthropologycum, 38(1), pp. 55–62. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24851597.
Ernawati, I. and Islamiyah, W. R. (2019). 'The relationship between adherence to the use of antiepileptic drugs and the incidence of seizures in epilepsy patients using the ARMS (Adherence Refill Medication Scale) questionnaire correlation between adherence to antiepileptic drugs usage measured with arms (adherence refill medication scale', 4(1), pp. 29–33.
Ernawati, I. and Islamiyah, W. R. (2021). Correlation of the level of compliance with antiepileptic drug consumption using the MGLs questionnaire (Morisky, Green Levine Adherence Scale) with the frequency of seizures in epilepsy patients, 10(2), pp. 2017–2021.
Fatmi, K. N., Roshinta, D., Dewi, L., & In’am Ilmiawan, M. (2022). The relation of duration of epilepsy, seizure frequency, and adherence with cognitive function in epilepsy patients, National Journal of Health Sciences (Jnik), 4(2621–6507), p. 52.
Ibrahim, Z. (2019). 'The relationship between medication adherence and seizure occurrence in epilepsy patients who were seizure-free for at least 1 year of treatment at the neurology clinic of Dr. A. Dadi Tjokrodipo Regional Hospital, Bandar Lampung in 2014', Journal of the Faculty of Medicine, 2(4), pp. 183–187.
Ikawati, Z. and Anurogo, D. (2018). Management of central nervous system disease therapy. Pert. Edition. Yogyakarta: Bursa Ilmu.
Kardas, P., Lawek, P. and Matyjaszczyk, M. (2013). Determinants of patient adherence: a review of systematic reviews, Frontiers in Pharmacology, 4, p. 91.
Ministry of Health of the Republic of Indonesia. (2017). 'National Guidelines for Medical Services for the Management of Epilepsy in Children', pp. 1–79.
Khairani, A.F. and Sejahtera, D. P. (2019). 'Epilepsy treatment strategies: monotherapy and polytherapy', Gajah Mada University, 18(3), pp. 115–119. Available at: https://journal.ugm.ac.id/bns/article/view/55017.
Lacy, C. F., Armstrong, L. L., and Goldman, M. P. (2010). Drug information handbook: a comprehensive resource for all clinicians and healthcare professionals (lexi comp's drug information handbooks).
Lee, J.W. and Dworetzky, B. (2010). Rational polytherapy with antiepileptic drugs pharmaceuticals, 3(8), pp. 2362–2379.
Mawuntu, A. H. P., Mahama, C. N., Sekeon, S. A. S., Winifred, K., & Khosama, H. (2019). Compliance with taking antiepileptic drugs in epilepsy patients in Manado, Indonesia, Journal Sinaps, 2(3), pp. 19–37.
Nanau, R. M. and Neuman, M. G. (2013). Adverse drug reactions induced by valproic acid, Pharmacology and Toxicology [Preprint].
PERDOSSI. 2014. Guidelines for the management of epilepsy. Fifth edition. Edited by K. Kusumastuti, S. Gunadharma, and E. Kustiowati. Surabaya: Airlangga University Press.
Permatananda, P. A. N., Budi A. P. I. and Harkitasari, S. (2019). 'Medication adherence and quality of life among epilepsy patients: a cross-sectional study', International Journal of Research, 7(3), pp. 1–10. Available at: https://doi.org/10.29121/granthaalayah.v7.i3.2019.937.
Ponnusamy, S. (2017). 'Electroencephalography images in epilepsy patients at the Haji Adam Malik Central General Hospital, September 2016-September 2017'.
Romoli, M., Mazzocchetti, P., D’Alanzo, R., Siliquini, S., & Elisa, V. (2019). 'Valproic acid and epilepsy: from molecular mechanisms to clinical evidence', 17(10), pp. 926–946.
Ruspanah, I. (2018). 'Characteristics of Anxiety in Epilepsy Patients in Ambon', Molucca Medica, 11(April), pp. 41–49. Available at: https://doi.org/10.30598/molmed.2018.v11.i1.41.
Sambono, V. G., Sugianto, P., Kasih, E., & Octavia, E. (2020). 'Study of the Use of the Combination of Phenytoin and Sodium Valproate on Serum Magnesium and the Number of Seizures in Epilepsy Patients at Dr. Soetomo Regional General Hospital', Journal of Pharmacy Science and Practice, 7(1), pp. 20–26. Available at: http://jurnal.wima.ac.id/index.php/JFST/article/view/2392.
Sanjiwani, K.S.F., Sugianto, P. and Kasih, E. (2019). 'Study of Phenytoin Drug Use for Less than Three Months on Serum Magnesium Levels and Number of Seizures in Epilepsy Patients at Dr. Soetomo Regional General Hospital, Surabaya', Journal of Pharmacy Science and Application, 4(2), pp. 57–63. Available at: http://jurnal.wima.ac.id/index.php/JFST/article/view/2180.
Saraswati, P. D., Samatra, D. P. G. P., Arimbawa, I. K., & Widyadharma, I. P. E. (2022). 'Characteristics of Outpatient Epilepsy Patients at Bali Mandara Regional Hospital in January – December 2019', Journal Medika Udayana, 11(01), pp. 25–29.
Sekarsari, K. (2020). 'The effect of the duration of phenytoin administration on executive function disorders in patients with tonic-clonic epilepsy', Periodical Journal of Neuroscience, 19(2), pp. 83–90.
Suryawijaya, N., Sam, C. I. L. and Gelgel, A. M. (2019). 'Description of Community Knowledge and Behavior Regarding Epilepsy in Kewapante District, Sikka Regency', Callosum Neurology, 2(3), pp. 90–97. Available at: https://doi.org/10.29342/cnj.v2i3.73.
Suryoputri, M. W., Endriastuti, N. E. and Ilma, D. L. (2021). 'Effects of Antiepileptic Drug Levels on Clinical Outcomes in Pediatric Patients Using Pharmacokinetics Approach', Indonesian Journal of Clinical Pharmacy, 10(4), pp. 272–288. Available at: https://doi.org/10.15416/ijcp.2021.10.4.272.
Tatum, W. O. (2010). 'Antiepileptic drugs: adverse effects and drug interactions', Continuum [Preprint].
Tedyanto, E. H., Chandra, L., & Adam, O. M. (2020). 'Overview of the Use of Anti-Epilepsy Drugs (AEDs) in Patients with Epilepsy Based on the Type of Seizure in the Neurology Clinic of DR. Ramelan Hospital, Surabaya', 2071 (November 2018), pp. 77–84.
WHO. (2022). Epilepsy. Available at: https://www.who.int/news-room/fact-sheets/detail/epilepsy.
Widyati, Soediatmoko, Ikawati, Z., & Hakim, L. (2013). 'Positive Impact of Clinical Pharmacy Services on Epilepsy Patients', Journal of Pharmaceutical Management and Services, pp. 217–222.
Wijayatri, R. (2012). Comparison of Monotherapy with Polytherapy in Controlling Seizures and the Occurrence of Drug Side Effects in Idiopathic Generalized Tonic Clonic Epilepsy at the Neurology Clinic of Dr. Sardjito General Hospital, Yogyakarta.