TWEEN, SPAN AND SONICATION TIME OPTIMIZATION OF CANDLENUT SEED EXTRACT NANOEMULSION (ALEURITES MOLUCCANA (L.) WILLD) CENTRAL COMPOSITE DESIGN APPLICATION
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Candlenut ethanol extract contains flavonoids and phenols that have benefits in the hair growth process. The formulation of the preparation into a nanoemulsion helps penetrate the stratum corneum of the scalp and keeps the flavonoids from being oxidized. Nanoemulsion is a dispersion of two liquids stabilized using a surfactant with a droplet size of 10 -100 nm. This research was conducted to obtain the optimal composition of tween 80, span 80 and sonication time. Data analysis usedstatistical analysis two-way Analysis of Variance (ANOVA) with 95% confidence level. This research is a quasi-experimental research using the optimization method of Central Composite Design. The factors used are tween 80, span 80 and sonication time. The nanoemulsion preparation was evaluated by conducting several physical properties tests such as organoleptic test, pH test, nanoemulsion type test, transmittance test, viscosity test, Freeze-thaw cycle and centrifugation test. From the statistical analysis of the two - way Analysis of Variance (ANOVA) the results that meet are the percent transmittance with a p-value of 0.040 (physical properties) and stability with a p-value of 0.016. The optimum points that meet the parameters of physical properties are F3, F4, F6, F7, F14 and F16. It is necessary to validate the recommended formula from theprogram Minitab 17 and it is necessary to test the activity of nanoemulsion preparations.
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