STUDY ON THE USE OF NON-STEROID ANTIINFLAMMATORY DRUGS (NSAIDS) IN RHEUMATOID ARTHRITIS AT RSU KUMALA SIWI

Abstract

Rheumatoid arthritis is an autoimmune disease that is characterized by joint inflammation and can occur chronically. This disease is a disease of declining immunity characterized by infection of the muscle membranes, especially in the joint tissues, often involving other organs of the body. Most sufferers show symptoms of chronic disease if not treated will worsen the condition and even lead to death. Objective: to find out how to use anti-inflammatory (NSAIDs) are sodium diclofenac, potassium diclofenac mefenamic acid, meloxicam, and ibuprofen drugs in rheumatoid arthritis output patients in the Kumala Siwi Kudus Hospital. Descriptive using a retrospective method and quantity. The types of NSAIDs given to patients at the Kumala Siwi Mijen Kudus General Hospital were ibuprofen (7.2%), Diclofenac Potassium (10.4%), Mefenamic Acid (10.4%), Meloxicam (17.6%) and Sodium Diclofenac (54.40%), there was an incidence of minor interactions based on the severity of major interactions (1.90%), moderate interactions (20.9%), and minor interactions (27.6%). While based on the level of pharmacodynamics interaction mechanism (62%), and pharmacokinetic interaction (3.77%). There is a relationship between the number of drugs with severity with a significance value of 0.20 and there is a relationship between the number of drugs and interactions based on mechanisms with a significance value of 0.018. The type of NSAID with the most sodium was diclofenac by 54.40%, and there were drug interactions based on severity and the largest mechanism of minor interactions were 29 cases (45%) and pharmacodynamics as many as 33 (62%). From these conclusions, there is a relationship between the number of drugs and drug interactions based on the severity and mechanism of the drug